Job Description

Sarmal, an innovative biotech company based in San Diego, California, is seeking a highly skilled R&D Scientist specializing in Enzyme Engineering to join our cutting-edge research team. We are developing revolutionary genomics platforms that aim to transform the fields of genetic testing and sequencing.

Key Responsibilities:

• Design and optimize enzymes for our proprietary TEEM and FLASH platforms
• Develop and conduct enzyme-substrate interaction studies
• Lead research projects focused on improving enzyme performance and stability
• Perform protein modifications to enhance enzymatic activity and specificity
• Develop and execute rate improvement assays under various conditions
• Collaborate with cross-functional teams to advance project goals
• Contribute to the development of intellectual property and patent applications

Required Qualifications:

• Ph.D. in Biochemistry, Molecular Biology, or a closely related field with a focus on enzyme engineering, purification and assay development/optimization
• 5+ years of post-doctoral experience in enzyme research and development
• Extensive hands-on experience with protein isolation and purification techniques
• Strong understanding of enzymatic assays and reaction buffer optimizations
• Proven expertise in protein modifications and enzyme kinetics
• Demonstrated ability to design and execute complex enzyme engineering experiments
• Excellent problem-solving skills and attention to detail
• Strong written and verbal communication skills

Preferred Qualifications:

• Industry experience in biotechnology or pharmaceutical sectors
• Extensive experience working with nucleic acid polymerases and modifying enzymes
• Strong background in modified nucleotides and their impact on enzyme activity
• Familiarity with next-generation sequencing technologies and their enzymatic foundations
• Experience with enzyme reaction optimization
• Track record of publications in peer-reviewed journals and/or patents in enzyme engineering
• Experience in project management and team leadership

We Offer:

• Competitive salary commensurate with experience
• Opportunity to work on groundbreaking enzyme engineering projects
• State-of-the-art laboratory facilities in La Jolla, CA
• Collaborative and innovative work environment
• Professional development and growth opportunities

Join our team of 10 members, along with advisors and consultants, and contribute to the development of disruptive technologies that aim to revolutionize genetic testing and sequencing.

Apply now to be part of our mission to advance global health through innovative research and development in enzyme engineering and genomics.

Sarmal is an equal opportunity employer and values diversity in our workforce.

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